Using online survey data from 1,146 pharmacists, researchers examine their perceptions about drug use, drug screening, interventions, and the commitment and readiness to address opioid use disorder and drug use disorder in their patients. The research includes breakdowns of pharmacist demographics as well as rurality of pharmacy locations. Pharmacists who were White, practiced at a rural location, worked at a chain pharmacy, had not received opioid-related training in the past year, or practiced screening patients for opioid use had elevated odds of perceiving concerns about opioid use problems in their practice settings. Having practiced pharmacy services for less time, and having received training for OUD-related preventive services within the last year, were associated with increased levels of commitment/readiness for providing care to patients with drug use problems.