A new practice guideline developed by the American Dental Association, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania School of Dental Medicine details acute pain management strategies. Nonsteroidal anti-inflammatory drugs taken alone or along with acetaminophen are recommended as first-line treatments for managing short-term dental pain in adults and adolescents aged 12 or older. Former PCOH Board Member/Board Chair Dr. Deborah Polk, University of Pittsburgh, was an author on this project.