The Center for Disease Control and Prevention’s (CDC) new COVID-19 Quarantine and Isolation (Q&I) Calculator is now available online. It is a mobile-friendly tool to help people follow quarantine and isolation guidance and receive customized information for their unique situations. It covers an easy-to-use way to figure out when and for how long people with COVID-19 and close contacts need to stay home, get tested, and wear a well-fitting mask and provides important information about what precautions people with COVID-19 and their close contacts can take to protect loved ones and slow the spread in their communities. It is not for people with COVID-19 who are moderately or severely ill, have a weakened immune system as they should talk with their healthcare provider for guidance, who can refer to the Ending Isolation and Precautions for People with COVID-19: Interim Guidance. Health systems can add the Quarantine and Isolation (Q&I) Calculator onto their websites by embedding the syndicated content code.