The U.S. Preventive Services Task Force seeks comments on a draft recommendation statement and draft evidence review on pre-exposure prophylaxis (PrEP) for the prevention of HIV infection. Based on its review of the evidence, the Task Force recommends that healthcare professionals prescribe PrEP to people at increased risk for HIV to help prevent HIV infection. The draft recommendation statement and draft evidence review are available for review and public comment from Dec. 13, 2022, to Jan. 17, 2023.