This week, a federal panel of experts issued new guidelines for people with HIV who are pregnant, have recently given birth, or are trying to conceive. Thanks to antiretroviral medications and other viral suppression strategies, parent-to-child transmission of HIV is less than 1 percent in the United States. The updated recommendations include new information about the use of antiretroviral drugs before and during pregnancy, guidance for pregnant people who have not achieved viral suppression, and infant feeding options. The Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV also co-authored sections published in the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Updates to these guidelines are anticipated in April 2023.