In a brief, the CDC reports that, between 2009 and 2018, the rate of overdose deaths involving cocaine rose significantly across all age groups, gender identities, and racial/ethnic categories. The overdose death rate in 2018 involving cocaine with concurrent use of opioids was triple the rate of those without any concurrent opioid use. Among all regions of the country—Northeast, Midwest, South, and West—rates were significantly lower in rural counties than in urban counties; however, the rate in Northeastern rural counties was about triple the rates of Midwestern, Southern, and Western rural counties.