Amazon’s recent acquisition of One Medical for $3.9 billion signals the tech giant is confident it can transform primary care in the United States. But while Amazon has tremendous resources — as well as a proven ability to turn economic sectors upside down — the company faces enormous challenges in blazing a new path through America’s huge, tangled health care sector. In their new article for Harvard Business Review, the Commonwealth Fund’s David Blumenthal, M.D., and Lovisa Gustafsson ask if profit-driven entrepreneurship and bottom-up innovation can finally take U.S. health care from worst to first. Read more.