Cancer prevention and early detection are central to the American Cancer Society’s (ACS) mission to save lives, celebrate lives, and lead the fight for a world without cancer. Early detection of cancer through screening reduces mortality from many cancers. Far too many individuals for whom screening is recommended remain unscreened, and this situation has been aggravated by the substantial decline in cancer screening resulting from the COVID-19 pandemic. Moreover, the pandemic-related disruptions will likely exacerbate existing disparities in cancer screening and survival across groups of people who have systemically experienced social or economic obstacles to screening and care. In response to these challenges, the American Cancer Society developed the ACS – Resuming Cancer Screening During COVID-19 Toolkit to summarize the current situation and to provide guidance on how public health agencies, healthcare providers, and screening advocates across the nation can promote and deliver cancer screening appropriately, safely and equitably during the pandemic.